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Design of Mobile X-Ray Scanner
Stejskal, Pavel ; Chorý, Tomáš (referee) ; Křenek, Ladislav (advisor)
Master thesis deals with creating a new design of mobile x-ray machine. Three studies of design were created on the base of processed analysis, when the best one were chosen and developed as a final design. The final design takes into account all egonomics and technical requirements and creates a machine with less technical and more favorable view for patients. Simplification and better arranged the control panels bring easier service for operators.
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Synthesis of chelators for use in diagnostic imaging
Kretschmer, Jan ; Polášek, Miloslav (advisor) ; Kubíček, Vojtěch (referee) ; Hrubý, Martin (referee)
Metals play a crucial role in medicine as a part of therapeutic or diagnostic preparations. However, in the majority of cases, their properties cannot be utilized entirely in free ionic form. Organic molecules capable of chelation are used to open the full potential of the metal. The molecules are called chelators and are the core theme of this thesis. The most important function of these molecules is the chelation and coordination of the metal, but chelators can provide other important functionalities. This work, therefore, focuses on the design, synthesis, and application of such polyfunctional chelators and is divided into two parts: DO3A-Hyp This part of the thesis deals with chelators that can be used as amino acids to incorporate lanthanides into peptides. The developed chelators provide a short and rigid connection of the metal to the peptide chain. Tripeptides containing two units of such chelators with a central amino acid bearing a CF3 group were synthesized to demonstrate the capability of DO3A-Hyp building blocks. Two paramagnetic metals were combined within this tripeptide, and it was shown that such a rigid and locked system could be used for combining their magnetic susceptibility tensors. These magnetic susceptibility tensors were used for manipulation of the 19 F NMR shift of the CF3...
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Design of Mobile X-Ray Scanner
Stejskal, Pavel ; Chorý, Tomáš (referee) ; Křenek, Ladislav (advisor)
Master thesis deals with creating a new design of mobile x-ray machine. Three studies of design were created on the base of processed analysis, when the best one were chosen and developed as a final design. The final design takes into account all egonomics and technical requirements and creates a machine with less technical and more favorable view for patients. Simplification and better arranged the control panels bring easier service for operators.
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Design of Mobile X-Ray Scanner
Stejskal, Pavel ; Křenek, Ladislav (advisor)
Master thesis deals with creating a new design of mobile x-ray machine. Three studies of design were created on the base of processed analysis, when the best one were chosen and developed as a final design. The final design takes into account all egonomics and technical requirements and creates a machine with less technical and more favorable view for patients. Simplification and better arranged the control panels bring easier service for operators.
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The Imaging in Cases of Obesity and the Metabolic Syndrome
DUŠKOVÁ, Radka
This thesis deals with imaging in cases of obesity and the metabolic syndrome. It mainly focuses on the diagnostic imaging using imaging modalities, such as skiagraphy,skiascopy, ultrasonography, computer telegraphy and magnetic resonance. The objective of this thesis was to determine the characteristic and specific qualities of various diagnostic procedures of a radiological assistant when imaging patients suffering from obesity and the metabolic syndrome, especially when a contrast medium is used during the treatment, and then to compare the diagnostic possibilities of imaging when different imaging modalities are used. The theoretical part describes obesity and the metabolic syndrome, with the special focus being done on their possible extent and resulting complications. Theimaging modalities do not image obesity and the metabolic syndrome as such, but deal with the diagnostics and the treatment of various illnesses caused by metabolic dysfunctions. The issue of diagnostic imaging is complicated by the differences in methods caused by the use or non-use of ionizing radiation. The increased risk of complications during the treatment of patients suffering from obesity and the metabolic syndrome can be caused by the use of a contrast medium, which is mostly used in diagnostic imaging and it is also sometimes used in therapeutic imaging, such the invasive treatment of the cardiovascular system. For this reason, this issue has also been dealt with in this thesis. The practical part contains an evaluation and a comparison of 100 questionnaires that have been filled in by randomly selected patients of the Radiological Department.The questionnaires were anonymous and those questions were created so as to determine the prevalence of obesity in the investigated sample, which would then provide information about the possible complications that can occur during an examination which have been caused by obesity and the metabolic syndrome. After completion of the questionnaire by these patients, I also participated in their examination and verified my presupposed hypothesis in practice. The results of the questionnaire research and the participation in the examination of respondents confirmed my hypothesis that imaging in obesity and the metabolic syndrome requires a special approach, especially when contrast mediums are used during the treatment. Attention has to be paid not only to the technical modifications of procedures in individual imaging modalities, but also to the specifications connected with organ polymorbidity and the related complicating pathological conditions. Since the prevalence of obesity and the metabolic syndrome is increasing, it is very probable that we will meet patients suffering from this type of illness increasingly more often at the Radiological Department. This is another reason why the specificities of imaging patients suffering from these illnesses should be gradually implemented into regular radiological imaging procedures.
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